Endocrine Abstracts

A 64 year old man presented in 1992 with a dense bitemporal hemianopia and no endocrine symptoms. CT showed a large pituitary adenoma with suprasellar extension. He underwent transphenoidal resection of the tumour. Histology showed a typical chromophobe adenoma with no immunohistochemical staining. His vision recovered.He was followed regularly with serial MRI scan. No change was seen in the size of the residual intrasellar tumour. Pituitary testing show...

Background: Numerous studies have provided evidence of the link between low testosterone levels and obesity, cardiovascular disease and type 2 diabetes. A recent UK study revealed 20% of type 2 diabetics had testosterone levels <8 nmol/l and 31% between 8 and 12 nmol/l. Hypogonadism in men can present with a variety of clinical symptoms which could include erectile dysfunction (ED). However, diabetic patients infrequently volunteer information regarding ED and is often not...

A 45 year old female with Type 1 DM for 12 years presented with malaise and frequent episodes of hypoglycaemia. Thyroxine was titrated to 150 mcg once daily over 2 months because TSH was 94 mIU/L [0.2–5.50 mIU/L]. However, her malaise and hypoglycaemia deteriorated, she also developed dense hyperpigmentation in the skin.Primary hypoadrenalism was confirmed by lack of response to 250 mcg IV Tetracosactide (Serum Cortisol at Time 0 min: 98 nmol/L; Ti...